Volume 2, 2023

ISSN 2817-0245 (Print)

Online first article

Decreased Function of Regulatory T cells with Low HDAC9 Expression in Renal Fibrosis

Minhui Xi, Jingyuan Lu, Hualin Qi

Department of Nephrology, Shanghai Pudong New Area People's Hospital, Shanghai, China. 

Abstract

Renal fibrosis, characterized by excessive deposition of extracellular matrix in the kidney, plays a pivotal role in the progression of chronic kidney disease (CKD) and ultimately leads to end-stage renal disease. Recent research has shed light on the crucial involvement of regulatory T cells (Tregs) in modulating the fibrotic process within the kidney. In this study, we examined Treg functions and mechanisms in renal fibrosis. Data showed that Treg frequencies were lower in renal fibrosis patients. Also, IL-17+ CD4+ T cells were increased in patients. Furthermore, Treg cells from patients presented reduced functions and reduced expression of Treg-related genes, in which HDAC9 expression was significantly lower in renal fibrosis. In conclusion, our results showed reduced function of Tregs in renal fibrosis.

Key words

Treg; HDAC9; renal fibrosis.

Pages: 1-6.

Online first article

How does COVID-19 affect arts?

Chelsey Adams

Stanford University, Stanford, CA, USA

Abstract

One of the biggest industries to be hit by the coronavirus pandemic has been the entertainment industry. When COVID-19 caused widespread shutdowns of businesses, arts and entertainment were hit hard. And unlike other industries, such as retail and food service, for the most part, the fine and performing arts have not been able to reopen or bounce back. Optimistically, with vaccines being administered at a successful rate, it may not be too far off for when museums, venues, and other performing centers can reopen. In the meantime, the entertainment industry needs to assess its path to recovery, as well as advocate for its importance both economically and culturally. Here are three insights about the current state of the entertainment industry and its economic importance.

Key words

COVID-19; arts; industry.

Pages: 1-2.

Online first article

LncRNA NORAD Regulates Treg Cell Activation in Gastric Cancer

Qi zhu, Yijun Xu, Zhe Wang, Yingxia Wu, Shuang He, Honggang Xiang

Department of General Surgery, Pudong New Area People’s Hospital, Shanghai, China.

Abstract

Gastric cancer is a complex and challenging disease with a high global incidence and mortality rate. Treg cells, a specialized subset of regulatory T cells, have gained attention in recent years due to their immunosuppressive function in various malignancies, including gastric cancer. In this study, we evaluated Lnc RNA-NORAD+ Treg cells in gastric cancer. First, data showed that the frequency of CD25hiFoxp3+ Treg cells was significantly elevated in gastric cancer patients. We also found that the total Treg cells could be subdivided into NORAD+CD28−, NORAD+CD28+, NORAD−CD28+, and NORAD−CD28−subsets and the NORAD+CD28− subset was significantly elevated in cancer patients than in healthy controls. IL10 and TGFB1 mRNA transcription levels were markedly higher in NORAD+CD28−and NORAD+CD28+ Treg cells than in NORAD−CD28−and NORAD−CD28+ Treg cells. Overall, these data suggest that LncRNA NORAD regulates treg cell activation in gastric cancer.

Key words

 Gastric cancer, NORAD, Treg.

Pages: 1-6.

Online first article

The future of design industry: artificial Intelligence-directed design process. 

Gayla Nelson

University of Toronto, Toronto, ON, Canada

Key words

Artificial Intelligence; design; industry.

Pages: 1-2.

Online first article

The impact of digital media design on E-travel business.

Abbie Jones

Yale University, New Haven, CT, USA

Key words

Digital media; design; E-travel business.

Pages:1-2

Online first article

Barriers to Secondary Prevention of Osteoporotic Fractures: A Comprehensive Review.

Xiaoting Qiu, Ying Yang, Rui Huang, Chaochen Qian, Yunrui Huo.

Department of Social Work, Shanghai Pudong New Area People’s Hospital, Shanghai, China

Key words

Secondary prevention; osteoporotic fractures.

Pages:1-4

ISSN 2817-0245 (Print)

1. About this journal

The editorial office

2. Basic leucine zipper activating transcription as a prognostic marker for cancer immunotherapy.

Shuai Han (1), Xinghai Yang, Jiayi Yan, Ting Wang, Dongjie Jiang, Jingyun Hu, Zongchang Song, Xingpeng Zhang, Jian Wang 

1. Shanghai Pudong New Area People's Hospital, Shanghai, China

7. Cell-mediated cytotoxicity as a contributor of antitumor immunity in oral squamous cell carcinoma.

Zhenyu Song (1)

1. DICAT Biomedical Computation Centre, Vancouver, BC, Canada 

12. Understanding T cell exhaustion and mitochondrial dysfunction in hepatocellular carcinoma.

Gaoqian Feng (1)

1. Burnet Institute, Melbourne, Australia 

14. A newly developed nomogram for predicting the risk of deep vein thrombosis after surgery.

Zhenyu Song (1)

1. DICAT Biomedical Computation Centre, Vancouver, BC, Canada 

16. Synovial fluid B cells from osteoarthritis produce elevated levels of proinflammatory chemokines.

Xiaoyan Li (1)

1. Beijing Tiantan Hospital, Capital Medical University, Beijing, China 

18. CD4 T cells induce matrix metalloproteinase expression in intracranial aneurysms.

Gaoqian Feng (1)

1. Burnet Institute, Melbourne, Australia